BiopestPeptidV1, Main, Exploration, bibRecord, 000796

Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry.

Identifieur interne : 000796 ( Main/Exploration ); précédent : 000795; suivant : 000797

Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry.

Source :

Scientific reports [ 2045-2322 ] ; 2018.

RBID : pubmed:29487327

Descripteurs français

KwdFr :
- Animaux (MeSH), Antibactériens (pharmacologie), Canal anal (microbiologie), Canards (MeSH), Chine (MeSH), Colistine (pharmacologie), Columbidae (MeSH), Escherichia coli (effets des médicaments et des substances chimiques), Escherichia coli (génétique), Escherichia coli (pathogénicité), Nez (microbiologie), Oies (MeSH), Partie orale du pharynx (microbiologie), Poulets (MeSH), Protéines Escherichia coli (génétique), Protéines membranaires (génétique), Résistance bactérienne aux médicaments (MeSH), Suidae (MeSH), Transferases (other substituted phosphate groups) (génétique), Volaille (MeSH).
MESH :
- effets des médicaments et des substances chimiques : Escherichia coli.
- génétique : Escherichia coli, Protéines Escherichia coli, Protéines membranaires, Transferases (other substituted phosphate groups).
- microbiologie : Canal anal, Nez, Partie orale du pharynx.
- pathogénicité : Escherichia coli.
- pharmacologie : Antibactériens, Colistine.
- Animaux, Canards, Chine, Columbidae, Oies, Poulets, Résistance bactérienne aux médicaments, Suidae, Volaille.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Anal Canal (microbiology), Animals (MeSH), Anti-Bacterial Agents (pharmacology), Chickens (MeSH), China (MeSH), Colistin (pharmacology), Columbidae (MeSH), Drug Resistance, Bacterial (MeSH), Ducks (MeSH), Escherichia coli (drug effects), Escherichia coli (genetics), Escherichia coli (pathogenicity), Escherichia coli Proteins (genetics), Geese (MeSH), Membrane Proteins (genetics), Nose (microbiology), Oropharynx (microbiology), Poultry (MeSH), Swine (MeSH), Transferases (Other Substituted Phosphate Groups) (genetics).
MESH :
- chemical , genetics : Escherichia coli Proteins, Membrane Proteins, Transferases (Other Substituted Phosphate Groups).
- chemical , pharmacology : Anti-Bacterial Agents, Colistin.
- geographic : China.
- drug effects : Escherichia coli.
- genetics : Escherichia coli.
- microbiology : Anal Canal, Nose, Oropharynx.
- pathogenicity : Escherichia coli.
- Animals, Chickens, Columbidae, Drug Resistance, Bacterial, Ducks, Geese, Poultry, Swine.

Abstract

Antimicrobial resistance against colistin has emerged worldwide and is threatening the efficacy of colistin treatment of multi-resistant Gram-negative bacteria. In this study, PCRs were used to detect mcr genes (mcr-1, mcr-2, mcr-3) in 213 anal and 1,339 nasal swabs from pigs (n = 1,454) in nine provinces of China, and 1,696 cloacal and 1,647 oropharyngeal samples from poultry (n = 1,836) at live-bird markets in 24 provinces. The mcr-1 prevalences in pigs (79.2%) and geese (71.7%) were significantly higher than in chickens (31.8%), ducks (34.6%) and pigeons (13.1%). The mcr-2 prevalence in pigs was 56.3%, significantly higher than in chickens (5.5%), ducks (2.3%), geese (5.5%) and pigeons (0%). The mcr-3 prevalences in pigs (18.7%), ducks (13.8%) and geese (11.9%) were significantly higher than in chickens (5.2%) and pigeons (5.1%). In total, 173 pigs and three chickens were positive for all three mcr genes. The prevalences of the mcr were significantly higher in nasal/oropharyngeal swabs than in the anal /cloacal swabs. Phylogenetic studies identified 33 new mcr-2 variants and 12 new mcr-3 variants. This study demonstrates high prevalences of mcr in pigs and poultry in China, and indicates there is need for more thorough surveillance and control programs to prevent further selection of colistin resistance.

DOI: 10.1038/s41598-018-22084-4
PubMed: 29487327
PubMed Central: PMC5829079

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000927
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Le document en format XML

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<author><name sortKey="Zhang, Jilei" sort="Zhang, Jilei" uniqKey="Zhang J" first="Jilei" last="Zhang">Jilei Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
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<author><name sortKey="Butaye, Patrick" sort="Butaye, Patrick" uniqKey="Butaye P" first="Patrick" last="Butaye">Patrick Butaye</name>
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<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Bacteriology and Poultry diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Pathology, Bacteriology and Poultry diseases, Faculty of Veterinary Medicine, Ghent University, Ghent</wicri:regionArea>
<orgName type="university">Université de Gand</orgName>
<placeName><settlement type="city">Gand</settlement>
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<author><name sortKey="Kelly, Patrick" sort="Kelly, Patrick" uniqKey="Kelly P" first="Patrick" last="Kelly">Patrick Kelly</name>
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<country xml:lang="fr">Saint-Christophe-et-Niévès</country>
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<author><name sortKey="Gong, Jiansen" sort="Gong, Jiansen" uniqKey="Gong J" first="Jiansen" last="Gong">Jiansen Gong</name>
<affiliation wicri:level="1"><nlm:affiliation>Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu, China.</nlm:affiliation>
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<wicri:regionArea>Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu</wicri:regionArea>
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<author><name sortKey="Guo, Weina" sort="Guo, Weina" uniqKey="Guo W" first="Weina" last="Guo">Weina Guo</name>
<affiliation wicri:level="1"><nlm:affiliation>College of Animal Science, Anhui Science and Technology University, Bengbu, 230001, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science, Anhui Science and Technology University, Bengbu, 230001</wicri:regionArea>
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<author><name sortKey="Li, Jing" sort="Li, Jing" uniqKey="Li J" first="Jing" last="Li">Jing Li</name>
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<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
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<author><name sortKey="Li, Min" sort="Li, Min" uniqKey="Li M" first="Min" last="Li">Min Li</name>
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<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
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<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
<wicri:noRegion>225009</wicri:noRegion>
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<author><name sortKey="Feng, Zhixing" sort="Feng, Zhixing" uniqKey="Feng Z" first="Zhixing" last="Feng">Zhixing Feng</name>
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<wicri:regionArea>Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, National Center for Engineering Research of Veterinary Bio-Products, Nanjing, 210014</wicri:regionArea>
<wicri:noRegion>210014</wicri:noRegion>
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<author><name sortKey="Jiang, Ping" sort="Jiang, Ping" uniqKey="Jiang P" first="Ping" last="Jiang">Ping Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea>
<wicri:noRegion>210095</wicri:noRegion>
</affiliation>
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<author><name sortKey="Song, Chunlian" sort="Song, Chunlian" uniqKey="Song C" first="Chunlian" last="Song">Chunlian Song</name>
<affiliation wicri:level="1"><nlm:affiliation>Yunnan Agricultural University College of Animal Science & Technology, Kunming, Yunnan, 650201, China.</nlm:affiliation>
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<wicri:regionArea>Yunnan Agricultural University College of Animal Science & Technology, Kunming, Yunnan, 650201</wicri:regionArea>
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<author><name sortKey="Wang, Yaoyao" sort="Wang, Yaoyao" uniqKey="Wang Y" first="Yaoyao" last="Wang">Yaoyao Wang</name>
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<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
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<author><name sortKey="You, Jinfeng" sort="You, Jinfeng" uniqKey="You J" first="Jinfeng" last="You">Jinfeng You</name>
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<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
<wicri:noRegion>225009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Yi" sort="Yang, Yi" uniqKey="Yang Y" first="Yi" last="Yang">Yi Yang</name>
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<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
<wicri:noRegion>225009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Price, Stuart" sort="Price, Stuart" uniqKey="Price S" first="Stuart" last="Price">Stuart Price</name>
<affiliation wicri:level="2"><nlm:affiliation>College of Veterinary Medicine, Auburn University, Auburn, AL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Veterinary Medicine, Auburn University, Auburn, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qi, Kezong" sort="Qi, Kezong" uniqKey="Qi K" first="Kezong" last="Qi">Kezong Qi</name>
<affiliation wicri:level="1"><nlm:affiliation>Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, 230036, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, 230036</wicri:regionArea>
<wicri:noRegion>230036</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kang, Yuan" sort="Kang, Yuan" uniqKey="Kang Y" first="Yuan" last="Kang">Yuan Kang</name>
<affiliation wicri:level="2"><nlm:affiliation>College of Veterinary Medicine, Auburn University, Auburn, AL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Veterinary Medicine, Auburn University, Auburn, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Chengming" sort="Wang, Chengming" uniqKey="Wang C" first="Chengming" last="Wang">Chengming Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China. wangche@auburn.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>College of Veterinary Medicine, Auburn University, Auburn, AL, USA. wangche@auburn.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Veterinary Medicine, Auburn University, Auburn, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29487327</idno>
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<idno type="doi">10.1038/s41598-018-22084-4</idno>
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<idno type="wicri:Area/Main/Corpus">000927</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry.</title>
<author><name sortKey="Zhang, Jilei" sort="Zhang, Jilei" uniqKey="Zhang J" first="Jilei" last="Zhang">Jilei Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
<wicri:noRegion>225009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Li" sort="Chen, Li" uniqKey="Chen L" first="Li" last="Chen">Li Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
<wicri:noRegion>225009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Jiawei" sort="Wang, Jiawei" uniqKey="Wang J" first="Jiawei" last="Wang">Jiawei Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
<wicri:noRegion>225009</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yassin, Afrah Kamal" sort="Yassin, Afrah Kamal" uniqKey="Yassin A" first="Afrah Kamal" last="Yassin">Afrah Kamal Yassin</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
<wicri:noRegion>225009</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Food Hygiene and safety, Faculty of Public and Environmental Health, Khartoum University, Khartoum, Sudan.</nlm:affiliation>
<country xml:lang="fr">Soudan</country>
<wicri:regionArea>Department of Food Hygiene and safety, Faculty of Public and Environmental Health, Khartoum University, Khartoum</wicri:regionArea>
<wicri:noRegion>Khartoum</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Butaye, Patrick" sort="Butaye, Patrick" uniqKey="Butaye P" first="Patrick" last="Butaye">Patrick Butaye</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis.</nlm:affiliation>
<country xml:lang="fr">Saint-Christophe-et-Niévès</country>
<wicri:regionArea>Department of Biosciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre</wicri:regionArea>
<wicri:noRegion>Basseterre</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, Bacteriology and Poultry diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of Pathology, Bacteriology and Poultry diseases, Faculty of Veterinary Medicine, Ghent University, Ghent</wicri:regionArea>
<orgName type="university">Université de Gand</orgName>
<placeName><settlement type="city">Gand</settlement>
<region>Région flamande</region>
<region type="district" nuts="2">Province de Flandre-Orientale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kelly, Patrick" sort="Kelly, Patrick" uniqKey="Kelly P" first="Patrick" last="Kelly">Patrick Kelly</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biosciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis.</nlm:affiliation>
<country xml:lang="fr">Saint-Christophe-et-Niévès</country>
<wicri:regionArea>Department of Biosciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre</wicri:regionArea>
<wicri:noRegion>Basseterre</wicri:noRegion>
</affiliation>
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<author><name sortKey="Li, Jing" sort="Li, Jing" uniqKey="Li J" first="Jing" last="Li">Jing Li</name>
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<author><name sortKey="Li, Min" sort="Li, Min" uniqKey="Li M" first="Min" last="Li">Min Li</name>
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<author><name sortKey="Yang, Feng" sort="Yang, Feng" uniqKey="Yang F" first="Feng" last="Yang">Feng Yang</name>
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<author><name sortKey="Feng, Zhixing" sort="Feng, Zhixing" uniqKey="Feng Z" first="Zhixing" last="Feng">Zhixing Feng</name>
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<wicri:regionArea>Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, National Center for Engineering Research of Veterinary Bio-Products, Nanjing, 210014</wicri:regionArea>
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<author><name sortKey="Jiang, Ping" sort="Jiang, Ping" uniqKey="Jiang P" first="Ping" last="Jiang">Ping Jiang</name>
<affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095</wicri:regionArea>
<wicri:noRegion>210095</wicri:noRegion>
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<author><name sortKey="Song, Chunlian" sort="Song, Chunlian" uniqKey="Song C" first="Chunlian" last="Song">Chunlian Song</name>
<affiliation wicri:level="1"><nlm:affiliation>Yunnan Agricultural University College of Animal Science & Technology, Kunming, Yunnan, 650201, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Yunnan Agricultural University College of Animal Science & Technology, Kunming, Yunnan, 650201</wicri:regionArea>
<wicri:noRegion>650201</wicri:noRegion>
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<author><name sortKey="Wang, Yaoyao" sort="Wang, Yaoyao" uniqKey="Wang Y" first="Yaoyao" last="Wang">Yaoyao Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
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<author><name sortKey="You, Jinfeng" sort="You, Jinfeng" uniqKey="You J" first="Jinfeng" last="You">Jinfeng You</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009</wicri:regionArea>
<wicri:noRegion>225009</wicri:noRegion>
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<author><name sortKey="Yang, Yi" sort="Yang, Yi" uniqKey="Yang Y" first="Yi" last="Yang">Yi Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
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</affiliation>
</author>
<author><name sortKey="Price, Stuart" sort="Price, Stuart" uniqKey="Price S" first="Stuart" last="Price">Stuart Price</name>
<affiliation wicri:level="2"><nlm:affiliation>College of Veterinary Medicine, Auburn University, Auburn, AL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Veterinary Medicine, Auburn University, Auburn, AL</wicri:regionArea>
<placeName><region type="state">Alabama</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qi, Kezong" sort="Qi, Kezong" uniqKey="Qi K" first="Kezong" last="Qi">Kezong Qi</name>
<affiliation wicri:level="1"><nlm:affiliation>Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, 230036, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, 230036</wicri:regionArea>
<wicri:noRegion>230036</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kang, Yuan" sort="Kang, Yuan" uniqKey="Kang Y" first="Yuan" last="Kang">Yuan Kang</name>
<affiliation wicri:level="2"><nlm:affiliation>College of Veterinary Medicine, Auburn University, Auburn, AL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Veterinary Medicine, Auburn University, Auburn, AL</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Chengming" sort="Wang, Chengming" uniqKey="Wang C" first="Chengming" last="Wang">Chengming Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China. wangche@auburn.edu.</nlm:affiliation>
<country wicri:rule="url">États-Unis</country>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>College of Veterinary Medicine, Auburn University, Auburn, AL, USA. wangche@auburn.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>College of Veterinary Medicine, Auburn University, Auburn, AL</wicri:regionArea>
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<series><title level="j">Scientific reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anal Canal (microbiology)</term>
<term>Animals (MeSH)</term>
<term>Anti-Bacterial Agents (pharmacology)</term>
<term>Chickens (MeSH)</term>
<term>China (MeSH)</term>
<term>Colistin (pharmacology)</term>
<term>Columbidae (MeSH)</term>
<term>Drug Resistance, Bacterial (MeSH)</term>
<term>Ducks (MeSH)</term>
<term>Escherichia coli (drug effects)</term>
<term>Escherichia coli (genetics)</term>
<term>Escherichia coli (pathogenicity)</term>
<term>Escherichia coli Proteins (genetics)</term>
<term>Geese (MeSH)</term>
<term>Membrane Proteins (genetics)</term>
<term>Nose (microbiology)</term>
<term>Oropharynx (microbiology)</term>
<term>Poultry (MeSH)</term>
<term>Swine (MeSH)</term>
<term>Transferases (Other Substituted Phosphate Groups) (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Antibactériens (pharmacologie)</term>
<term>Canal anal (microbiologie)</term>
<term>Canards (MeSH)</term>
<term>Chine (MeSH)</term>
<term>Colistine (pharmacologie)</term>
<term>Columbidae (MeSH)</term>
<term>Escherichia coli (effets des médicaments et des substances chimiques)</term>
<term>Escherichia coli (génétique)</term>
<term>Escherichia coli (pathogénicité)</term>
<term>Nez (microbiologie)</term>
<term>Oies (MeSH)</term>
<term>Partie orale du pharynx (microbiologie)</term>
<term>Poulets (MeSH)</term>
<term>Protéines Escherichia coli (génétique)</term>
<term>Protéines membranaires (génétique)</term>
<term>Résistance bactérienne aux médicaments (MeSH)</term>
<term>Suidae (MeSH)</term>
<term>Transferases (other substituted phosphate groups) (génétique)</term>
<term>Volaille (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Escherichia coli Proteins</term>
<term>Membrane Proteins</term>
<term>Transferases (Other Substituted Phosphate Groups)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Colistin</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Escherichia coli</term>
<term>Protéines Escherichia coli</term>
<term>Protéines membranaires</term>
<term>Transferases (other substituted phosphate groups)</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Canal anal</term>
<term>Nez</term>
<term>Partie orale du pharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Anal Canal</term>
<term>Nose</term>
<term>Oropharynx</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Escherichia coli</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term>
<term>Colistine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Chickens</term>
<term>Columbidae</term>
<term>Drug Resistance, Bacterial</term>
<term>Ducks</term>
<term>Geese</term>
<term>Poultry</term>
<term>Swine</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Canards</term>
<term>Chine</term>
<term>Columbidae</term>
<term>Oies</term>
<term>Poulets</term>
<term>Résistance bactérienne aux médicaments</term>
<term>Suidae</term>
<term>Volaille</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
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<front><div type="abstract" xml:lang="en">Antimicrobial resistance against colistin has emerged worldwide and is threatening the efficacy of colistin treatment of multi-resistant Gram-negative bacteria. In this study, PCRs were used to detect mcr genes (mcr-1, mcr-2, mcr-3) in 213 anal and 1,339 nasal swabs from pigs (n = 1,454) in nine provinces of China, and 1,696 cloacal and 1,647 oropharyngeal samples from poultry (n = 1,836) at live-bird markets in 24 provinces. The mcr-1 prevalences in pigs (79.2%) and geese (71.7%) were significantly higher than in chickens (31.8%), ducks (34.6%) and pigeons (13.1%). The mcr-2 prevalence in pigs was 56.3%, significantly higher than in chickens (5.5%), ducks (2.3%), geese (5.5%) and pigeons (0%). The mcr-3 prevalences in pigs (18.7%), ducks (13.8%) and geese (11.9%) were significantly higher than in chickens (5.2%) and pigeons (5.1%). In total, 173 pigs and three chickens were positive for all three mcr genes. The prevalences of the mcr were significantly higher in nasal/oropharyngeal swabs than in the anal /cloacal swabs. Phylogenetic studies identified 33 new mcr-2 variants and 12 new mcr-3 variants. This study demonstrates high prevalences of mcr in pigs and poultry in China, and indicates there is need for more thorough surveillance and control programs to prevent further selection of colistin resistance.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29487327</PMID>
<DateCompleted><Year>2019</Year>
<Month>09</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>09</Month>
<Day>23</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>02</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Scientific reports</Title>
<ISOAbbreviation>Sci Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry.</ArticleTitle>
<Pagination><MedlinePgn>3705</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1038/s41598-018-22084-4</ELocationID>
<Abstract><AbstractText>Antimicrobial resistance against colistin has emerged worldwide and is threatening the efficacy of colistin treatment of multi-resistant Gram-negative bacteria. In this study, PCRs were used to detect mcr genes (mcr-1, mcr-2, mcr-3) in 213 anal and 1,339 nasal swabs from pigs (n = 1,454) in nine provinces of China, and 1,696 cloacal and 1,647 oropharyngeal samples from poultry (n = 1,836) at live-bird markets in 24 provinces. The mcr-1 prevalences in pigs (79.2%) and geese (71.7%) were significantly higher than in chickens (31.8%), ducks (34.6%) and pigeons (13.1%). The mcr-2 prevalence in pigs was 56.3%, significantly higher than in chickens (5.5%), ducks (2.3%), geese (5.5%) and pigeons (0%). The mcr-3 prevalences in pigs (18.7%), ducks (13.8%) and geese (11.9%) were significantly higher than in chickens (5.2%) and pigeons (5.1%). In total, 173 pigs and three chickens were positive for all three mcr genes. The prevalences of the mcr were significantly higher in nasal/oropharyngeal swabs than in the anal /cloacal swabs. Phylogenetic studies identified 33 new mcr-2 variants and 12 new mcr-3 variants. This study demonstrates high prevalences of mcr in pigs and poultry in China, and indicates there is need for more thorough surveillance and control programs to prevent further selection of colistin resistance.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Jilei</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jiawei</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yassin</LastName>
<ForeName>Afrah Kamal</ForeName>
<Initials>AK</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Food Hygiene and safety, Faculty of Public and Environmental Health, Khartoum University, Khartoum, Sudan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Butaye</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Biosciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology, Bacteriology and Poultry diseases, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kelly</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Biosciences, Ross University School of Veterinary Medicine, PO Box 334, Basseterre, Saint Kitts and Nevis.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gong</LastName>
<ForeName>Jiansen</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Weina</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>College of Animal Science, Anhui Science and Technology University, Bengbu, 230001, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Min</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Feng</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Zhixing</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, National Center for Engineering Research of Veterinary Bio-Products, Nanjing, 210014, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Ping</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Chunlian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Yunnan Agricultural University College of Animal Science & Technology, Kunming, Yunnan, 650201, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Yaoyao</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>You</LastName>
<ForeName>Jinfeng</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Yi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu, 225009, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Price</LastName>
<ForeName>Stuart</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>College of Veterinary Medicine, Auburn University, Auburn, AL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qi</LastName>
<ForeName>Kezong</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, 230036, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kang</LastName>
<ForeName>Yuan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>College of Veterinary Medicine, Auburn University, Auburn, AL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Chengming</ForeName>
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   |wiki=    Bois
   |area=    BiopestPeptidV1
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   |type=    RBID
   |clé=     pubmed:29487327
   |texte=   Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry.
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	Serveur d'exploration sur les peptides biopesticides
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Serveur d'exploration sur les peptides biopesticides

Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry.

Molecular detection of colistin resistance genes (mcr-1, mcr-2 and mcr-3) in nasal/oropharyngeal and anal/cloacal swabs from pigs and poultry.

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